Pressure-induced fast axonal transport abnormalities and the anatomy at the lamina cribrosa in primate eyes.
نویسنده
چکیده
In ten owl monkey eyes (Aotus trivirgatus) the location of pressure-induced (perfusion pressure 35 mmHg) axonal transport abnormalities was determined by the examination of serial step cross-section tissue radio autographs from the optic nerve head. The degree of the local transport interruption did not correlate with the fiber bundle cross-section area, the shape of the laminar pores or the density of the inter-bundle septa in that region.
منابع مشابه
Reversibility of optic nerve damage in primate eyes subjected to intraocular pressure above systolic blood pressure.
It was shown previously that pressure-induced interruption of axonal transport at the optic nerve head is reversible after 8 hours of raised intraocular pressure (perfusion pressure of 25 to 35 mmHg). Here we report experiments on the nature, location, and reversibility of pressureinduced abnormalities of the optic nerve head, including interruption in axonal transport, in eyes subjected to a m...
متن کاملReversibility of optic nerve damage in primate eyes sub jected to intraocular pressure above systolic blood pressure RONALD
It was shown previously that pressure-induced interruption of axonal transport at the optic nerve head is reversible after 8 hours of raised intraocular pressure (perfusion pressure of 25 to 35 mmHg). Here we report experiments on the nature, location, and reversibility of pressureinduced abnormalities of the optic nerve head, including interruption in axonal transport, in eyes subjected to a m...
متن کاملThe dynamics and location of axonal transport blockade by acute intraocular pressure elevation in primate optic nerve.
Axonal transport in primate optic nerve axons was studied by autoradiography, scintillation counting, and electron microscopy under conditions of short-term intraocular pressure elevation. With elevation of intraocular pressure to 30 mm. Hg below mean arterial blood pressure, blockage of transport was detected within 2 hours by autoradiography and within 1 hour by electron microscopy. The earli...
متن کاملAxonal transport and cytoskeletal changes in the laminar regions after elevated intraocular pressure.
PURPOSE To investigate the axonal cytoskeleton changes occurring in the prelaminar region, lamina cribrosa, and postlaminar region of the porcine optic nerve after an acute increase in intraocular pressure (IOP) and whether this corresponds with axonal transport abnormalities. METHODS Six white Landrace pigs were used. The left eye IOP was elevated to 40 to 45 mm Hg for 6 hours, and the right...
متن کاملMorphology of axonal transport abnormalities in primate eyes RONALD
The ultrastructure of the retina and optic nerve head was studied in primate eyes after central retinal artery occlusion. Within 2 hours of the vascular occlusion the inner retinal layers undergo watery (isosmotic) swelling. This watery swelling of axons and astroglia extends into the nerve head as far back as the anterior boundary of the scleral lamina cribrosa. The swelling is increased 4 hou...
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ورودعنوان ژورنال:
- Investigative ophthalmology & visual science
دوره 24 3 شماره
صفحات -
تاریخ انتشار 1983